Development of Next-Generation Peptide Binders Using In vitro Display Technologies and Their Potential Applications
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چکیده
منابع مشابه
Development of Next-Generation Peptide Binders Using In vitro Display Technologies and Their Potential Applications
During the last decade, a variety of monoclonal antibodies have been developed and used as molecular targeting drugs in medical therapies. Although antibody drugs tend to have intense pharmacological activities and negligible side effects, several issues in their development and prescription remain to be resolved. Synthetic peptides with affinities and specificities for a desired target have re...
متن کاملIn vitro methods for peptide display and their applications.
The presentation of recombinant peptide libraries linked to their coding sequence can be referred to as 'peptide display'. Phage display is the most widely practiced peptide display technology but more recent alternatives such as CIS display, ribosome display and mRNA display offer advantages over phage for speed, library size and the display of unnatural amino acids. These have provided resear...
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Abstract DNA sequencing is one of the great valuable techniques in molecular biology, which can be used to detect the sequence of nucleotides in a DNA fragment. The high-throughput sequencing known as Next Generation Sequencing (NGS) revolutionized genomic research and molecular biology; therefore, the whole human genome can be sequenced with a low cost in several days. NGS technology is simi...
متن کاملStrategies and Clinical Applications of Next Generation Sequencing
Abstract DNA sequencing is one of the great valuable techniques in molecular biology, which can be used to detect the sequence of nucleotides in a DNA fragment. The high-throughput sequencing known as Next Generation Sequencing (NGS) revolutionized genomic research and molecular biology; therefore, the whole human genome can be sequenced with a low cost in several days. NGS technology is simi...
متن کاملDevelopment of Peptide Binders
Yang, J. 2017. Development of Peptide Binders. Applied to Human CRP, Carbonic Anhydrase (II, IX) and Lysine Demethylase 1. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology 1568. 60 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0086-3. In this thesis, a polypeptide binder concept is illustrated. By conjugation to a set of sixteen ...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2013
ISSN: 1664-3224
DOI: 10.3389/fimmu.2013.00224